Digestive System Channel
Related Channels

Zegerid OTC Warnings and Precautions

Specific Precautions and Warnings With Zegerid OTC

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Studies indicate that people who take proton pump inhibitor medications (such as Zegerid OTC) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Proton pump inhibitors (PPIs), including Zegerid OTC, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. Make sure your doctor knows if you have been taking an over-the-counter (OTC) PPI drug, such as Zegerid OTC, for a long time. 


  • Make sure to see a healthcare provider if you have any symptoms that suggest your heartburn may actually be a more serious problem. Such symptoms may include:
    • Heartburn for more than three months
    • Heartburn with lightheadedness, dizziness, or sweating
    • Chest pain, shoulder pain, or any other heart attack symptoms
    • Frequent wheezing, especially with heartburn
    • Unexplained weight loss
    • Nausea and vomiting
    • Abdominal pain (stomach pain)
    • Needing to take Zegerid OTC for more than a 14-day course once every four months.
  • Zegerid OTC is used for a 14-day course of treatment, with repeated courses allowed once every four months. However, many people who take medications like Zegerid OTC need to take them on a long-term basis. There is no reason that Zegerid OTC cannot be used for a long period of time, except that an evaluation by a healthcare provider is warranted, to rule out the possibility of more serious problems.
If your healthcare provider recommends that you take Zegerid OTC for longer than 14 days, you may completely disregard the label directions that warn against doing so.
  • Some of the symptoms of heartburn or gastroesophageal reflux disease (GERD) are similar to symptoms of stomach cancer. Just because Zegerid OTC helps your symptoms does not rule out the possibility of stomach cancer.
  • Zegerid OTC can interact with other medications (see Zegerid OTC Drug Interactions).
  • Check with your healthcare provider before taking Zegerid OTC if you have an electrolyte imbalance or acid-base imbalance, as the sodium carbonate in this medication could cause problems for you.
  • Each Zegerid OTC capsule provides 303 mg of sodium. This is important for people who are on a low-sodium diet.
  • Zegerid OTC is considered a pregnancy Category C medication. This means that this medication may not be safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using Zegerid OTC during pregnancy (see Zegerid OTC and Pregnancy).
  • Zegerid OTC passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Zegerid OTC and Breastfeeding).

Zegerid OTC Medication Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2018 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.