Triamterene-HCTZ is used for the treatment of fluid retention and high blood pressure. By increasing the amount of water and salt removed from the blood, it causes a decrease in blood volume, which can help lower blood pressure. There are no approved triamterene-HCTZ uses in children, and there are no universally accepted off-label uses for the medicine.
Triamterene-HCTZ should be used only in people who develop low potassium levels (hypokalemia) while taking hydrochlorothiazide or in people who cannot risk low potassium levels due to other medical conditions.
In previous clinical studies, triamterene-HCTZ has been shown to significantly lower both systolic and diastolic blood pressures. By lowering blood pressure, the medication can decrease the risk of developing health problems -- such as a stroke, heart disease, or congestive heart failure -- that often occur with long-term high blood pressure(see Effects of High Blood Pressure). However, triamterene-HCTZ is not a cure for high blood pressure.