If certain medications are combined, there is a possibility of negative drug interactions. With triamterene-HCTZ, these interactions can affect the potassium levels in your blood and may increase your risk of side effects. Among the drugs that can potentially cause drug interactions with triamterene-HCTZ are NSAIDs, corticosteroids, and lithium. To prevent these drug interactions with triamterene-HCTZ from occurring, your healthcare provider may adjust your dosages.