Drug Interactions With Triamterene-HCTZ

If certain medications are combined, there is a possibility of negative drug interactions. With triamterene-HCTZ, these interactions can affect the potassium levels in your blood and may increase your risk of side effects. Among the drugs that can potentially cause drug interactions with triamterene-HCTZ are NSAIDs, corticosteroids, and lithium. To prevent these drug interactions with triamterene-HCTZ from occurring, your healthcare provider may adjust your dosages.

An Overview of Drug Interactions With Triamterene-HCTZ

Triamterene-HCTZ (Dyazide^®, Maxzide^®) can potentially interact with a number of other medicines. Some of the medicines that can lead to triamterene-HCTZ drug interactions include:

ACE inhibitors, including:
- Benazepril (Lotensin^®)
- Captopril (Capoten^®)
- Enalapril (Vasotec^®)
- Fosinopril (Monopril^®)
- Lisinopril (Prinivil^®, Zestril^®)
- Quinapril (Accupril^®)
- Ramipril (Altace^®)

Amiloride (Midamor^®)
Amphotericin B (Amphocin^®, Abelcet^®, AmBisome^®, Amphotec^®)
Angiotensin II receptor blockers (ARBs), such as:

Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
Candesartan (Atacand^®) or candesartan-hydrochlorothiazide (Atacand HCT^®)
Eprosartan (Teveten^®) or eprosartan-hydrochlorothiazide (Teveten^® HCT)
Irbesartan (Avapro^®) or irbesartan-hydrochlorothiazide (Avalide^®)
Losartan (Cozaar^®) or losartan-hydrochlorothiazide (Hyzaar^®)
Olmesartan (Benicar^®), olmesartan-hydrochlorothiazide (Benicar HCT^®), or amlodipine and olmesartan (AZOR™)
Telmisartan (Micardis^®) or telmisartan-hydrochlorothiazide (Micardis^® HCT)
Valsartan (Diovan^®) or valsartan-hydrochlorothiazide (Diovan HCT^®)

Other blood pressure medicines
Corticosteroids, such as:
- Prednisone
- Hydrocortisone (Cortef^®)
- Dexamethasone (Decadron^®, Dexone^®, Hexadrol^®)

Digoxin (Digitek^®, Lanoxin^®)
Laxatives
Lithium (Eskalith^®, Lithobid^®)
Methenamine (Hiprex^®, Urex^®)
Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex^®)
- Diclofenac (Cataflam^®, Voltaren^®)
- Etodolac (Lodine^®)
- Ibuprofen (Motrin^®, Advil^®)
- Indomethacin (Indocin^®, Indocin SR^®)
- Ketoprofen
- Ketorolac (Toradol^®)
- Meloxicam (Mobic^®)
- Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
- Nabumetone (Relafen^®)
- Oxaprozin (Daypro^®)

Potassium-containing products, such as:
- Potassium chloride (K-Dur^®, Klor-Con^®, Micro-K^®)
- Potassium citrate (Urocit-K^®, Polycitra-K^®)
- Potassium gluconate
- Potassium phosphate (Neutra-Phos-K^®, K-Phos^®)
- Salt substitutes (used to flavor food)