Drug Interactions With Triamterene-HCTZ
Triamterene-HCTZ should be used with caution in people taking digoxin. Triamterene-HCTZ can cause low potassium levels (hypokalemia) or high potassium levels (hyperkalemia), both of which can be especially dangerous for people taking digoxin.
Triamterene-HCTZ may be less effective in people who overuse laxatives or who use laxatives chronically. Ask your healthcare provider about using laxatives while taking triamterene-HCTZ.
Taking triamterene-HCTZ with lithium may raise the level of lithium in your blood, potentially increasing your chance of side effects. It is generally not recommended that you take lithium with diuretics, including triamterene-HCTZ. Depending on your situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
Nonsteroidal Anti-Inflammatory Drugs
Combining triamterene-HCTZ with nonsteroidal anti-inflammatory drugs (NSAIDs) can make triamterene-HCTZ less effective and may increase your risk of side effects. To prevent this interaction from occurring, your healthcare provider may need to increase your dose of triamterene-HCTZ or may suggest an alternative to NSAIDs.
Taking methenamine with triamterene-HCTZ may make methenamine less effective. Talk with your healthcare provider about taking these medications together.
In general, potassium-containing products should not be used with triamterene-HCTZ, due to the risk of high potassium levels (hyperkalemia).
Triamterene-HCTZ should not be taken with spironolactone. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).