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Drug Interactions With Triamterene-HCTZ (Cont.)

Interactions With Triamterene-HCTZ Explained

The following sections explain in detail the potentially negative interactions that can occur when triamterene-HCTZ is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining triamterene-HCTZ with ACE inhibitors can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly while you are taking the drug.
 
Amiloride
Triamterene-HCTZ should not be taken with amiloride. Taking these two medications together increases your risk of high potassium levels (hyperkalemia).
 
Amphotericin B
Amphotericin B can increase your chances of low potassium levels when combined with triamterene-HCTZ. Depending on your individual situation, your healthcare provider should check your potassium levels and may need to take steps to correct it.
 
Angiotensin II Receptor Blockers
Combining triamterene-HCTZ with angiotensin II receptor blockers (ARBs) can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should check your potassium levels regularly if you are taking these medications together.
 
Other Blood Pressure Medicines
When taking triamterene-HCTZ with another high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of this triamterene-HCTZ interaction, your healthcare provider may monitor you more closely and change the dose of either medicine.
 
Corticosteroids
Taking triamterene-HCTZ with corticosteroids may increase your risk of low potassium levels (hypokalemia). Your healthcare provider should check your potassium levels during treatment, and may need to take steps to correct it.
(Drug Interactions With Triamterene-HCTZ Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;