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Tegaserod

How Does Tegaserod Work?

Tegaserod works by stimulating certain serotonin receptors in the digestive tract. This helps the muscles of the digestive tract to move food through more quickly, which helps to treat and prevent constipation. The medicine also helps to make the nerves in the digestive tract less sensitive, leading to decreased feelings of pain and bloating.
 

Effects of Tegaserod

There have been several studies looking at how well tegaserod treats IBS with constipation and chronic idiopathic constipation.
 
Irritable Bowel Syndrome (IBS) With Constipation
Several studies have looked at using tegaserod for IBS with constipation in women. In these studies, women were asked to rate their symptoms of IBS as: completely relieved, considerably relieved, somewhat relieved, unchanged, or worse.
 
In these studies, 31 to 35 percent of women who took tegaserod felt completely or considerably relieved after the first month, compared to 17 to 22 percent of women who did not take tegaserod. More women (both those who took tegaserod and those who did not) felt completely or considerably relieved after three months of treatment.
 
Two studies have looked at this medication as a possible IBS medication in men. These studies did not show any difference between the men who took tegaserod and the men who did not. This could mean that tegaserod is not effective for IBS in men, or it could mean that the studies did not look at enough men to be able to notice a difference.

Tegaserod Maleate

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