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Sunitinib Side Effects

Common Side Effects

Sunitinib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients) or a different medication. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo or the other medicine.
 
In these studies, the most common sunitinib side effects included:
 
  • Diarrhea -- in up to 66 percent of people
  • Fatigue -- up to 62 percent
  • Nausea -- up to 58 percent
  • Mouth sores, inflammation, or pain -- up to 48 percent (see Mouth and Gum Problems During Chemotherapy)
  • Loss of appetite -- up to 48 percent
  • Changes in taste -- up to 47 percent
  • Vomiting -- up to 39 percent
  • Abdominal pain (stomach pain) -- up to 39 percent
  • Bleeding events, including nosebleed or abnormal bleeding -- up to 37 percent
  • Heartburn or indigestion -- up to 34 percent
  • High blood pressure (hypertension) -- up to 34 percent
  • Loss of energy or strength -- up to 34 percent.
     
Other common reactions, occurring in 10 to 30 percent of people, included:
 
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