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Sunitinib Dosage

Dose of Sunitinib for Pancreatic Neuroendocrine Tumors (PNET)

The usual sunitinib dosage for the treatment of PNET (a type of cancer of the pancreas) is 37.5 mg once daily. The medicine is generally taken continuously, with no breaks. Doses above 50 mg daily have not been studied in clinical trials.
 
Sunitinib doses may be adjusted by 12.5 mg, based on an individual's response. For example, the amount may be decreased by 12.5 mg if intolerable or serious side effects occur, or increased by 12.5 mg if the medicine does not appear to be effective.
 
People taking certain other medications may need higher or lower sunitinib dosages (see Drug Interactions With Sunitinib). The maximum recommended dose for people with RCC and GIST is 87.5 mg daily, while the maximum recommended amount for people with PNET is 62.5 mg daily.
 

General Information on Taking Sunitinib

Some considerations to keep in mind during sunitinib include the following:
 
  • This medication comes in the form of a capsule. It is usually taken by mouth once a day.
     
  • You can take a dose of sunitinib with or without food.
     
  • Sunitinib should be swallowed whole. Do not crush, chew, cut, or open the capsules.
     
  • Try to take your dosage at the same time each day to keep an even level of the drug in your bloodstream. Taking the medicine at the same time each day will also help you remember to take it.
     
  • Do not drink grapefruit juice or eat grapefruit while taking this medication.
     
  • For the medication to work properly, it must be taken as prescribed. 
     
  • If you are unsure about anything related to your dosage or dosing with sunitinib, please talk with your healthcare provider, nurse, or pharmacist.
     
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