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Drug Interactions With Sunitinib

QT-Prolonging Medications
Sunitinib can cause a certain change in the heart rhythm known as QT prolongation. Taking sunitinib with other medications that may cause QT prolongation can increase your risk for this potentially life-threatening problem. Your healthcare provider may need to monitor you for this if you take sunitinib with another QT-prolonging medication.
 
Natalizumab
Combining sunitinib with natalizumab may increase your risk for developing infections, including potentially serious infections. It is generally recommended that these medications not be taken together.
 
Pimecrolimus
In general, people taking sunitinib should not use pimecrolimus because of an increased risk for infection, lymphoma (cancer of the lymph nodes), and skin cancer. Talk to your healthcare provider before taking these medicines together.
 
Silodosin
Taking sunitinib with silodosin may increase your silodosin blood levels, possibly increasing your risk for side effects. Do not take these medicines together unless your healthcare provider tells you otherwise.
 
Sipuleucel-T
Taking sunitinib with sipuleucel-T may make sipuleucel-T less effective. Talk to your healthcare provider before taking these medicines together.
 
Tacrolimus Ointment
Combining sunitinib with tacrolimus ointment may increase your risk for potentially serious side effects, including infections, skin cancer, and lymphoma (cancer of the lymph nodes). You should talk to your healthcare provider before taking these medicines together.
 
Temsirolimus
There have been reports of serious side effects in people who took temsirolimus in combination with sunitinib, including severe rash, blood clotting problems, and gout. Because of these reports, it may be best to avoid taking these medicines together, unless absolutely necessary. Talk to your healthcare provider before combining these drugs.
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Sunitinib Drug Information

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