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Drug Interactions With Sunitinib

More Detail on Drug Interactions With Sunitinib

The following sections explain in detail the potentially negative interactions that can occur when sunitinib is combined with any of the drugs mentioned above.
 
Bevacizumab
Combining bevacizumab with sunitinib may increase your risk for a certain type of anemia and for high blood pressure (hypertension). These medicines should not be used together unless your healthcare provider tells you otherwise. If they are used together, your healthcare provider may need to monitor you more closely.
 
CYP 3A4 Inducer Medications
The body breaks down sunitinib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining sunitinib with one of these drugs may decrease the level of sunitinib in your body, potentially making it less effective.
 
It is generally recommended that sunitinib not be combined with CYP 3A4 inducers. If your healthcare provider recommends taking such medicines together, he or she may need to give you a higher sunitinib dosage.
 
CYP 3A4 Inhibitor Medications
The body breaks down sunitinib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining sunitinib with one of these drugs may increase the level of sunitinib in your body, potentially increasing your risk for side effects.
 
It is generally recommended that sunitinib not be taken with strong CYP 3A4 inhibitors. If, however, you take sunitinib with one of these drugs, your healthcare provider may need to reduce your sunitinib dose.
 
Dabigatran
Sunitinib may increase the level of dabigatran in your blood, potentially increasing your risk for side effects, such as bleeding. Your healthcare provider may need to lower your dabigatran dose if you take it with sunitinib.
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Sunitinib Drug Information

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