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Precautions and Warnings With Rabeprazole Sprinkle

Rabeprazole sprinkle may increase your risk of breaking a bone or developing a serious type of diarrhea. It can also cause problems for those who have liver disease or low blood magnesium levels. To help ensure your safety, talk to your healthcare provider about your medical history before starting treatment. Other warnings and precautions with rabeprazole sprinkle apply to people with certain allergies.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking rabeprazole sprinkle (Aciphex® Sprinkle™) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Low blood magnesium levels (hypomagnesemia)
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Rabeprazole Sprinkle Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • As with other proton pump inhibitor (PPI) medications, rabeprazole sprinkle may increase the risk for developing Clostridium difficile–associated diarrhea (CDAD). CDAD occurs when an infection in the intestines with the bacteria Clostridium difficile causes severe diarrhea. CDAD is potentially serious. Let your healthcare provider know right away if you develop diarrhea that does not go away or watery stool with abdominal (stomach) pain and fever.
  • Studies suggest that PPIs may increase the risk for breaking a bone of the hip, wrist, or spine. The risk appears to be highest in people who take multiple daily doses of PPIs and use them for over a year. Rabeprazole sprinkle is only approved for use in children for up to 12 weeks, and should be used at the lowest dose needed for the shortest amount of time.
  • Like other PPIs, rabeprazole sprinkle can cause low blood magnesium levels (hypomagnesemia) if used for at least three months. In most cases, this side effect occurred in people taking PPIs for over a year. Your healthcare provider may choose to check your blood magnesium levels before you start treatment and periodically thereafter, especially if you will be taking rabeprazole sprinkle for a long time. Let your healthcare provider know right away if you develop any symptoms of hypomagnesemia, such as:
    • Muscle spasms
    • An irregular heartbeat
    • Seizures.
  • This medication should be used cautiously in people with severe liver disease. Make sure your healthcare provider knows if you have liver disease before being treated with rabeprazole sprinkle.
  • Rabeprazole sprinkle is a pregnancy Category B medication, which means it is probably safe for use during pregnancy, although the full risks are currently unknown (see Aciphex Sprinkle and Pregnancy).
  • It is unknown if rabeprazole sprinkle passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Aciphex Sprinkle and Breastfeeding).
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Rabeprazole Sprinkle Drug Information

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