Primary biliary cirrhosis is a disease that slowly destroys the liver's bile ducts and can even make the liver stop working. Although some research suggests that this disease may be caused by a problem within the immune system, the exact cause of this condition is unknown. Itchy skin and fatigue are the most common symptoms of primary biliary cirrhosis. Treatment options for the disease may include dietary supplements, hormone therapy, and medications to treat the specific symptoms caused by this condition.