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What Is Orally Disintegrating Metoclopramide Used For?

The FDA has licensed orally disintegrating metoclopramide for the treatment of GERD and gastroparesis due to diabetes. Off-label uses include the treatment of nausea and vomiting, and to stimulate the production of breast milk. The medication is generally taken four times a day. It has several effects on the digestive tract and also blocks dopamine receptors. Children should not use orally disintegrating metoclopramide.

Approved Uses for Orally Disintegrating Metoclopramide

Orally disintegrating metoclopramide (Metozolv™ ODT) is a prescription medication approved for the short-term treatment of the following conditions:
 

Using Orally Disintegrating Metoclopramide for Diabetic Gastroparesis

Gastroparesis, also called delayed gastric emptying, is a disorder in which the stomach takes too long to empty its contents. It often occurs in people with diabetes (both type 1 and type 2). The condition occurs when nerves to the stomach are damaged or stop working, which can happen if diabetes is poorly controlled over a long period.
 
Signs and symptoms of diabetic gastroparesis include:
 
  • Heartburn
  • Nausea
  • Vomiting of undigested food
  • An early feeling of fullness when eating
  • Weight loss
  • Abdominal bloating
  • Erratic blood glucose levels
  • Lack of appetite
  • Gastroesophageal reflux
  • Spasms of the stomach wall.
     
If food lingers too long in the stomach, it can cause problems, like bacterial overgrowth from the fermentation of food. Also, the food can harden into solid masses called bezoars that may cause nausea, vomiting, and obstruction in the stomach. Bezoars can be dangerous if they block the passage of food into the small intestine.
 
Diabetic gastroparesis can make diabetes worse by adding to the difficulty of controlling blood glucose (blood sugar). When food that has been delayed in the stomach finally enters the small intestine and is absorbed, blood glucose levels rise. Since diabetic gastroparesis makes stomach emptying unpredictable, a person's blood glucose levels can be erratic and difficult to control as a result.
 
Orally disintegrating metoclopramide can only be used to treat diabetic gastroparesis for two to eight weeks.
 
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Orally Disintegrating Metoclopramide Information

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