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Precautions and Warnings With Orally Disintegrating Metoclopramide

People who have certain medical conditions, such as Parkinson's disease, depression, congestive heart failure, or cirrhosis of the liver, may need to avoid orally disintegrating metoclopramide. Warnings and precautions also apply to women who are pregnant or may become pregnant, or who are breastfeeding. In addition, this medication may cause withdrawal symptoms when treatment is stopped.

What Should I Tell My Healthcare Provider?

Prior to taking orally disintegrating metoclopramide (Metozolv™ ODT), talk to your healthcare provider if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
In addition, tell your healthcare provider about all the medicines you take, including prescription and nonprescription drugs, vitamins, and herbal supplements.

Specific Orally Disintegrating Metoclopramide Warnings and Precautions

Some warnings and precautions to be aware of with orally disintegrating metoclopramide include the following:
  • Orally disintegrating metoclopramide can cause a group of bothersome and sometimes disturbing side effects known as extrapyramidal symptoms (EPS). These symptoms include:
    • Unusual body, facial, or tongue movements
    • Muscle tension or contractions
    • Feelings of internal restlessness or jitteriness. 
It is important to contact your healthcare provider right away if you develop EPS, since letting it go too long increases the chance of the symptoms becoming permanent, even after the medication is stopped.
  • Orally disintegrating metoclopramide is approved for short-term use only (no more than 12 weeks). Taking it longer increases the risk of permanent extrapyramidal symptoms.
  • This medication may cause depression. Some cases are mild, while others are quite severe and may involve suicidal thinking or behavior. Tell your healthcare provider if you have depression or even a history of depression. If you start to notice any symptoms of depression while taking orally disintegrating metoclopramide, contact your healthcare provider.
  • Orally disintegrating metoclopramide can cause symptoms that look like Parkinson's disease. It can also make Parkinson's disease worse. In general, people with this condition should avoid this medicine.
  • This drug can cause a life-threatening condition called neuroleptic malignant syndrome (NMS). Some symptoms of NMS include:
    • A high fever
    • Stiff muscles
    • Confusion
    • Irregular pulse or blood pressure
    • A fast heart rate (tachycardia)
    • Sweating
    • Irregular heart rhythms (arrhythmias). 
Tell your healthcare provider right away if think you might have NMS. 
  • Orally disintegrating metoclopramide could make high blood pressure, congestive heart failure, and cirrhosis worse. If you have any of these conditions, check with your healthcare provider before taking this medicine.
  • Some people may experience withdrawal symptoms, such as dizziness, nervousness, or headaches, after stopping orally disintegrating metoclopramide.
  • Orally disintegrating metoclopramide can interact with other medications (see Drug Interactions With Orally Disintegrating Metoclopramide).
  • Orally disintegrating metoclopramide is usually considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using this drug when pregnant (see Metozolv ODT and Pregnancy for more information).
  • This medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk with your healthcare provider before beginning treatment (see Metozolv ODT and Breastfeeding for more information).
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Orally Disintegrating Metoclopramide Information

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