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Orally Disintegrating Metoclopramide

What Should I Tell My Healthcare Provider?

Prior to taking this medication, talk to your healthcare provider if you have:
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medications, vitamins, and herbal supplements.
(Click Precautions and Warnings With Orally Disintegrating Metoclopramide to learn more, including information on who should not take the drug.)

How Does Orally Disintegrating Metoclopramide Work?

The active ingredient in orally disintegrating metoclopramide (metoclopramide) is a medication that has several actions in the digestive tract. It causes the esophageal sphincter (which closes the opening from the stomach up to the esophagus) to become more tight while causing the pyloric sphincter (which closes the opening from the stomach out to the intestines) to relax.
The drug also increases the muscular contractions of the stomach and small intestines.
All of these actions work together to help food move through the stomach more quickly, which is why orally disintegrating metoclopramide is effective for diabetic gastroparesis treatment. The medication has little or no activity in the colon.
Orally disintegrating metoclopramide helps with GERD by preventing the stomach contents from refluxing back up the esophagus, since it increases the tightness of the esophageal sphincter.
The drug works to relieve nausea and vomiting by blocking dopamine receptors in the brain, although this is an "off-label" (rather than an approved) use. Dopamine can activate the part of the brain that controls nausea and vomiting, and blocking the receptors helps to alleviate these problems.
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Orally Disintegrating Metoclopramide Information

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