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Orally Disintegrating Metoclopramide Dosage

The usual dose of orally disintegrating metoclopramide is 10 or 15 mg, taken four times a day. However, in some cases, a single 20-mg dosage will be recommended. Various factors affect the amount your healthcare provides prescribes, including the condition being treated. The medication comes in the form of a tablet that is placed under the tongue, where it dissolves in about a minute.

An Introduction to Dosing With Orally Disintegrating Metoclopramide

The dosage of orally disintegrating metoclopramide (Metozolv™ ODT) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated or prevented
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Diabetic Gastroparesis

The recommend dose of orally disintegrating metoclopramide for treating diabetic gastroparesis is 10 mg four times daily -- taken at least 30 minutes before meals and at bedtime -- for two to eight weeks.


The recommended orally disintegrating metoclopramide dosage for treating gastroesophageal reflux disease (GERD) is 10 or 15 mg four times daily, taken at least 30 minutes before meals and at bedtime. If symptoms occur only at a specific time of the day or only in response to certain foods or situations, a single dosage of 20 mg before the anticipated symptoms occur may be recommended, instead of taking it around-the-clock.
This medication is approved only for short-term treatment of GERD (up to 12 weeks).

General Information on Dosing With Orally Disintegrating Metoclopramide

Some considerations to keep in mind when taking orally disintegrating metoclopramide include the following:
  • This medication comes in the form of orally disintegrating tablets. The tablets are taken by mouth. Place the tablet on the tongue, let it dissolve, and then swallow. You do not need water to take the tablets.
  • On average, it takes about one minute for the tablet to dissolve on the tongue.
  • Orally disintegrating metoclopramide doses are usually taken four times a day, at least 30 minutes before meals and at bedtime. In some situations, less frequent dosing may be appropriate.
  • Do not take this medication with food or during a meal, since this can decrease the effectiveness of the medication.
  • Orally disintegrating metoclopramide is not approved to be used longer than 12 weeks at a time. Taking the medication longer increases the risk of serious side effects.
  • For this drug to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or orally disintegrating metoclopramide dosing in general, please talk with your doctor, nurse, or pharmacist.
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Orally Disintegrating Metoclopramide Information

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