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Drug Interactions With Orally Disintegrating Metoclopramide

Antipsychotics
Combining orally disintegrating metoclopramide with an antipsychotic medication may increase the risk of bothersome or disturbing side effects known as extrapyramidal symptoms (EPS). This may also increase the risk of neuroleptic malignant syndrome (NMS), a potentially dangerous side effect of orally disintegrating metoclopramide. In general, orally disintegrating metoclopramide should not be taken with antipsychotic medications.
 
Cyclosporine
Orally disintegrating metoclopramide could increase the amount of cyclosporine that is absorbed into the bloodstream, which could increase the chance of cyclosporine toxicity. Your healthcare provider may need to measure the level of cyclosporine in your blood and adjust your dosage, especially when you start or stop taking orally disintegrating metoclopramide.
 
Diabetes Medications
Orally disintegrating metoclopramide helps food move through the stomach more quickly. While this is usually a desirable result in people with diabetic gastroparesis, your healthcare provider may need to adjust the dosage and/or the timing of your diabetes drugs to account for this change.
 
Digoxin
Orally disintegrating metoclopramide may decrease the amount of digoxin that is absorbed into your bloodstream, perhaps making it less effective. Your healthcare provider may need to measure the level of digoxin in your blood and adjust your dosage, especially when you start or stop taking orally disintegrating metoclopramide.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking orally disintegrating metoclopramide with an MAOI may cause dangerous side effects. In general, it is best to avoid combining these medications.
 
Other Medications That Cause Drowsiness
Combining orally disintegrating metoclopramide with other medications that are prone to cause drowsiness may lead to severe drowsiness, confusion, or memory loss. Check with your healthcare provider before taking such medications together.
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Orally Disintegrating Metoclopramide Information

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