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Side Effects of Ondansetron Oral Soluble Film

Common Side Effects

Ondansetron oral soluble film was approved by the United States Food and Drug Administration (FDA) based on the safety and efficacy of Zofran®, the tablet form of ondansetron. Therefore, the information on potential side effects for ondansetron oral soluble film is actually taken directly from studies of Zofran tablets, not from studies of ondansetron oral soluble film specifically.
Zofran has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking Zofran were documented and then compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients).
In these studies, the most common Zofran side effects included:
  • Headaches -- occurring in up to 27 percent of people
  • Tiredness (fatigue) or a general ill feeling -- in up to 13 percent
  • Constipation -- in up to 9 percent (see Zofran and Constipation)
  • Low oxygen levels (when used for surgery) -- in up to 9 percent
  • Fever -- in up to 8 percent.
Other common side effects (occurring in 5 to 7 percent of people) included:
  • Diarrhea
  • Gynecological disorders (problems with the female reproductive system)
  • Anxiety or agitation
  • Difficulty emptying the bladder (urinary retention)
  • Itching
  • Dizziness.
Ondansetron oral soluble film works by blocking serotonin receptors. Serotonin is a chemical that is also important in depression. However, this medication works on different receptors than those that are related to depression, which explains why depression is not a potential side effect.
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Ondansetron Oral Soluble Film Information

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