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Precautions and Warnings with Ondansetron Oral Soluble Film

Before using ondansetron oral soluble film, there are many precautions to be aware of, including warnings relating to who should not use it and possible side effects that may occur. For instance, this prescription medicine may cause potentially serious problems, such as severe allergic reactions or changes in heart rhythm. Also, you may not be able to use this drug if you have liver problems.

What Should I Tell My Healthcare Provider Before Taking Ondansetron Oral Soluble Film?

You should talk with your healthcare provider prior to taking ondansetron oral soluble film (Zuplenz™) if you have:
 
  • Liver problems, including cirrhosis
  • An arrhythmia (an irregular heart rhythm), especially long QT syndrome
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant.
  • Are breastfeeding.
  • Have severe or constant nausea or vomiting that does not improve with ondansetron oral soluble film. Also, talk with your healthcare provider if you are vomiting blood.
  • Have severe vomiting and diarrhea. This combination of problems can lead to dehydration and electrolyte imbalances.
     
It's important to also tell your healthcare provider about any other medicines you are taking, including prescription and nonprescription medications, vitamins, and herbal supplements.
 

Specific Warnings and Precautions

Some warnings and precautions to be aware of before taking ondansetron oral soluble film include the following:
 
  • Rarely, ondansetron oral soluble film can cause changes in heart rhythm, including a specific type of arrhythmia called QT prolongation. People with long QT syndrome should not take this medication.
     
  • In rare cases, ondansetron oral soluble film can cause severe allergic reactions. Seek immediate medical attention if you develop any signs or symptoms of such a reaction, such as:
     
    • An unexplained rash
    • Hives
    • Itching
    • Wheezing or other difficulty breathing
    • Swelling of the mouth, lips, or throat.
 
  • Ondansetron oral soluble film can interact with certain medications (see Drug Interactions with Ondansetron Oral Soluble Film).
     
  • Ondansetron oral soluble film is considered a pregnancy Category B medication. This means that this medication is probably safe for use during pregnancy, although the full risks are currently unknown (see Zuplenz and Pregnancy for more information).
  • Ondansetron oral soluble film can cause changes in heart rhythm, including a specific type of arrhythmia called QT prolongation. People with long QT syndrome should not take this medication. People taking certain other medications, people with certain electrolyte imbalances, and people with heart disease may also be at an increased risk for QT prolongation with this drug.
 
  • It is not known if ondansetron oral soluble film passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, make sure to talk with your healthcare provider about the potential risks and benefits (see Zuplenz and Breastfeeding for more information).
     
  • Ondansetron oral soluble film does not increase the activity or movement of the gastrointestinal tract and should not be used for this purpose. Using this medicine after abdominal surgery or chemotherapy may mask the symptoms of an intestinal blockage (abdominal ileus). Talk to your healthcare provider right away if you are severely constipated or have abdominal cramping or bloating, as this may be a sign of intestinal blockage.
     
  • For people with poor liver function, a lower ondansetron oral soluble film dosage is typically recommended. The maximum dose of this medication for people with severe liver problems is 8 mg per day.
     
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Ondansetron Oral Soluble Film Information

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