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Drug Interactions With Ondansetron Oral Soluble Film
Before using ondansetron oral soluble film, make sure your healthcare provider is aware of any other medications you are taking (including nonprescription medicines and herbal supplements). Some products, such as tramadol, phenytoin, and rifampicin, can cause negative drug interactions when taken with ondansetron oral soluble film. These reactions can potentially cause side effects or decrease the effectiveness of the drugs.
Ondansetron oral soluble film (Zuplenz™) may potentially interact with a number of other medications. Some of the drugs that may lead to interactions with this product include but are not limited to:
- Apomorphine (Apokyn®)
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Phenytoin (Dilantin®, Phenytek®)
- Rifampicin (Rifadin®)
- Tramadol (Rybix™ ODT, Ryzolt®, Ultram®, Ultram® ER) or tramadol/acetaminophen (Ultracet®).
The following sections explain in detail the potential problems that can occur when ondansetron oral soluble film is combined with any of the drugs mentioned above.
Apomorphine
Taking ondansetron oral soluble film in combination with apomorphine may cause dangerously low blood pressure (hypotension) and loss of consciousness. These two medications should not be taken together.
Written by/reviewed by: Kristi Monson, PharmD
Last reviewed by: Kristi Monson, PharmD