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Misoprostol Side Effects

Clinical research has shown that some of the most commonly reported side effects of misoprostol include headaches, indigestion, and abdominal pain. Fortunately, most people tolerate this medicine well, and reactions to the drug tend to be minor. However, if you experience persistent diarrhea or decreased urination, tell your healthcare provider right away.

An Introduction to Side Effects of Misoprostol

Just like any medicine, misoprostol (Cytotec®) can cause side effects. However, not everyone who takes the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with misoprostol. Your healthcare provider can discuss a more complete list with you.)

Serious Misoprostol Side Effects

Some side effects of misoprostol are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
  • Severe or persistent diarrhea
  • Decreased urination
  • Extreme dizziness
  • Dry mouth, lips, or skin
  • Menstrual problems, including irregular or heavy periods.

Misoprostol Drug Information

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