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Misoprostol Side Effects

Common Side Effects

Misoprostol has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were documented and compared to those that occurred in a group of people taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they occurred, and how they compared to the placebo.
 
In these studies, the most common bothersome, but usually not dangerous, misoprostol side effects included:
 
  • Diarrhea -- in up to 40 percent of people
  • Abdominal (stomach) pain -- up to 20 percent
  • Nausea -- up to 3.2 percent
  • Gas -- up to 2.9 percent
  • Headache -- up to 2.4 percent
  • Heartburn or indigestion -- up to 2 percent
  • Vomiting -- up to 1.3 percent
  • Constipation -- up to 1.1 percent.
 

Other Reactions

Other uncommon side effects were also reported in clinical studies. Given how uncommon they are, it can be difficult to tell whether these problems are actually caused by the medication itself or by something else.
 
Some of these rare but possible misoprostol side effects include but are not limited to:
 
 

Misoprostol Drug Information

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