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Misoprostol Dosage

The recommended starting dosage for misoprostol is usually 200 mcg taken by mouth four times a day. If you develop intolerable side effects, your healthcare provider may lower this amount to 100 mcg four times daily. To help minimize diarrhea and other side effects, it may help to take this medication after a meal and take the last dose at bedtime.

An Introduction to Your Dosage of Misoprostol

The dose of misoprostol (Cytotec®) your healthcare provider recommends will vary, depending on how well you tolerate the medication. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Misoprostol Dosing Guidelines

The usual recommended misoprostol dosage for preventing gastric ulcers in people taking nonsteroidal anti-inflammatory drugs (NSAIDs) is 200 mcg four times a day. If this amount causes intolerable side effects, your healthcare provider may lower your dose to 100 mcg four times a day. The medication is usually continued for the duration of NSAID treatment.
Misoprostol can cause diarrhea. Taking the medication after a meal and taking the last dose of the day at bedtime may help reduce this complication.
On occasion, misoprostol is used for "off-label" uses, such as causing abortions or inducing labor; however, there are no official dosing recommendations for these types of uses.

General Information on Taking Misoprostol

Some considerations to keep in mind during treatment with misoprostol include the following:
  • This medication comes in tablet form. It is taken by mouth four times a day.
  • You should take a dose of misoprostol after a meal, and take your last dose of the day at bedtime.
  • Try to take this medication at the same time each day to keep an even level in your blood.
  • To help prevent an ulcer, you will need to take misoprostol as long as you are taking an NSAID.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or misoprostol dosing in general, please talk with your healthcare provider or pharmacist.

Misoprostol Drug Information

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