Digestive System Home > Prepopik

People who are about to have a colonoscopy may receive Prepopik to help cleanse the bowels before the procedure. This prescription medication comes as a powder that is mixed with water and taken in two separate doses. Unlike many other bowel-prep products, Prepopik has the lowest amount of solution that you must drink. Side effects may include headaches, nausea, and vomiting.

What Is Prepopik?

Prepopik® (sodium picosulfate/magnesium oxide/anhydrous citric acid) is a prescription medication licensed to cleanse the bowels before a colonoscopy in adults. This bowel cleansing is often called colonoscopy preparation or bowel prep. Of all the prescription bowel-prep products, this has the lowest volume of active ingredient you must drink (only two 5-ounce doses).
(Click Prepopik Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Prepopik is made by Ferring Pharmaceuticals, Inc.

How Does Prepopik Work?

The sodium picosulfate in this medication is a stimulant laxative. It stimulates the muscular movements of the colon to help clear out the contents. The other active ingredients (magnesium oxide and anhydrous citric acid) combine to form magnesium citrate, an osmotic laxative. Magnesium citrate works by drawing water into the colon, which softens the stool and causes watery bowel movements. The watery bowel movements flush waste from the intestines, cleaning them out.

Clinical Effects

Clinical studies have shown that Prepopik can effectively cleanse the bowel before a colonoscopy. In these studies, Prepopik was compared to a traditional "big jug" bowel prep medication, which was combined with stimulant laxative tablets. Prepopik was as effective as the traditional regimen.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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