If you do not take your lubiprostone as scheduled, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
How Does Lubiprostone Work?
Lubiprostone works by activating chloride channels in the intestines. This helps stimulate the flow of intestinal fluid, which, in turn, stimulates the movement of food through the intestines.
Clinical Studies on Lubiprostone
Studies have shown that lubiprostone works quickly to relieve constipation. In one study for chronic idiopathic constipation, as many as 62.9 percent of people who took the drug had a bowel movement within the first 24 hours, compared to just 31.9 percent of those who took a placebo (a "sugar pill" that does not contain any active ingredients). Lubiprostone also increased the number of bowel movements per week and reduced the symptoms of chronic constipation, such as abdominal discomfort and bloating. Long-term studies have demonstrated that this medication keeps working with continued use (it does not stop working over time).
Studies have also shown that lubiprostone can relieve symptoms of IBS in women. In one study, as many as 13.8 percent of people responded well to the medicine (which means that their symptoms were "significantly relieved" or "moderately relieved"), compared to just 7.8 percent of those who took a placebo. Studies have also shown that there was no "rebound" effect (a worsening of symptoms after the medication was stopped). Studies in men have not been large enough to determine if the medication is effective for this group.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: Approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed July 7, 2007.
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