Digestive System Home > Linaclotide

Linaclotide is taken once a day to treat irritable bowel syndrome with constipation and chronic idiopathic constipation. This prescription drug comes as a capsule and should be taken on an empty stomach. Side effects are possible and include diarrhea, gas, and abdominal (stomach) pain. If you have a bowel obstruction or are pregnant or nursing, it may not be safe to take linaclotide.

What Is Linaclotide?

Linaclotide (Linzess™) is a prescription medication approved to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (long-term constipation with no known cause). It is the first in a new class of medicines known as guanylate cyclase-C agonists (or simply GC-C agonists). Linaclotide is only approved for adults; it should not be used in children. 
 
(Click What Is Linaclotide Used For? for more information, including possible off-label uses.)
 

Are There Side Effects?

As with any medicine, linaclotide can cause side effects. However, not everyone who takes the drug will experience problems. Most people tolerate it quite well.
 
If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
 
Some of the most common side effects of linaclotide include but are not limited to:
 
  • Diarrhea
  • Abdominal (stomach) pain
  • Gas. 
 
(Click Linaclotide Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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