Digestive System Home > Linaclotide Side Effects

Some of the more common side effects seen with linaclotide include headaches, gas, and bloating. However, research has shown that most people who use linaclotide tolerate it well, and if problems do occur, they are generally minor and easy to treat. Contact your healthcare provider immediately if you develop severe diarrhea, an unexplained rash, or difficulty breathing while taking linaclotide.

An Introduction to Side Effects of Linaclotide

As with any medicine, linaclotide (Linzess™) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with linaclotide. Your healthcare provider can discuss a more complete list with you.)
  

Serious Linaclotide Side Effects

Some linaclotide side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Severe or persistent diarrhea
  • Severe abdominal (stomach) pain
  • Bright red, bloody, or tarry-looking stools
  • Signs of dehydration, such as:
    • Dizziness
    • Lightheadedness
    • Dry mouth
    • Feeling thirsty
 
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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