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Side Effects of Lubiprostone

Common Side Effects of Lubiprostone

Lubiprostone has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were documented and then compared to the side effects that occurred in another group of people not taking the medicine. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group not taking the medicine.
In these studies, the most common lubiprostone side effects included:
  • Nausea -- in up to 29 percent of people
  • Diarrhea -- up to 12 percent
  • Headaches -- up to 11 percent
  • Abdominal pain (stomach pain) -- up to 8 percent
  • Bloating -- up to 6 percent
  • Gas -- up to 6 percent.
Other common side effects (occurring in 1 to 5 percent of people) included:
  • Vomiting
  • Loose stools
  • Abdominal discomfort
  • Indigestion or heartburn
  • Dry mouth
  • Dizziness
  • Fatigue
  • Chest pain
  • Fluid retention
  • Shortness of breath.

Final Thoughts on Side Effects of Lubiprostone

You may experience some or none of the lubiprostone side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking the drug, or if you experience something that "just does not seem right." While it may not be a lubiprostone side effect, your healthcare provider will be able to diagnose and treat the problem.
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