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Precautions and Warnings With Lubiprostone

You may not be able to safely take lubiprostone if you have certain allergies or a gastrointestinal blockage caused by a physical problem. Also, make sure your healthcare provider is aware of any other medications you are taking (including vitamins and herbal supplements) before starting treatment. Other precautions and warnings with lubiprostone include the risk of severe diarrhea and the safety of taking it while pregnant or breastfeeding.

Lubiprostone: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking lubiprostone (Amitiza®) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A bowel blockage (obstruction)
  • Severe diarrhea
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Lubiprostone

Some warnings and precautions to be aware of prior to taking lubiprostone include the following:
  • Your healthcare provider should not prescribe lubiprostone for you if you have severe diarrhea. The medication is meant for people with constipation. Also, let your healthcare provider know if you develop severe or persistent diarrhea while taking it.
  • Lubiprostone has not been studied in people with liver or kidney disease. These conditions could affect the way your body handles the medication.
  • Nausea is one of the common side effects of lubiprostone. Taking the medication with food can help reduce this side effect.
  • Some people have reported shortness of breath and/or chest pain after taking their lubiprostone dosage. This is not usually considered a serious problem, but it may be unpleasant enough for people to stop taking the medication.
  • Lubiprostone is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Amitiza and Pregnancy).
  • It is not known if lubiprostone passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Amitiza and Breastfeeding).
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