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Lubiprostone Dosage

For women with irritable bowel syndrome with constipation, the recommended lubiprostone dosage is 8 mcg twice daily. The recommended dose for treating chronic idiopathic constipation in men and women is lubiprostone 24 mcg twice daily. However, before prescribing a lubiprostone dose, your healthcare provider will consider several factors, such as other medical conditions you may have.

Lubiprostone Dosage: An Introduction

The dose of lubiprostone (Amitiza®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • The medical condition being treated
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Dose of Lubiprostone for IBS

The recommended lubiprostone dose for treating irritable bowel syndrome (IBS) with constipation in women is lubiprostone 8 mcg twice daily with food and water. The medication is not approved for treating irritable bowel syndrome in men, as it has not yet been shown to be effective for this group. In people with impaired liver function, your dose may need to be reduced. For severe liver impairment, the recommended dose is 8 mcg once daily. Your healthcare provider will monitor your response and adjust accordingly.
 

Lubiprostone Dosage for Constipation

The recommended dose of lubiprostone for treating chronic idiopathic constipation (long-term constipation with no known cause) or constipation due to chronic opioid pain medication use is lubiprostone 24 mcg twice daily with food and water. It is approved for both men and women for these uses. 
 
In people with impaired liver function, your dose may need to be reduced. For moderate liver impairment, the recommended dose is 16 mcg twice daily. The recommended dose for severe liver impairment is 8 mcg twice daily. Your healthcare provider will monitor your response and adjust accordingly.
 
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Lubiprostone for IBS

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