Because living-donor liver transplantation is still a relatively new surgery, we don't have a lot of data on its long-term emotional or mental effects. In similar surgeries, like the over 55,000 living-donor kidney transplants that have been performed in the US, many donors go on to feel good about themselves and their decision to donate. They know that they have done something special to help someone else.

Some people worry about how their life will be affected by liver donation surgery. Though everyone's experience is different, most people continue to have a high quality of life after this surgery. Many donors even feel their quality of life improved after the surgery. In one study, six months after their surgery, several liver donors were asked to rate their quality of life since the surgery. Over 64% said it was the best time of their life. About 17% were in the medium range, and 9% said it was the worst time of their life.

Over 9 out of 10 liver or kidney donors say that if they had to do it over again, they would definitely still donate a liver section or kidney. However, a small percent say that they would not donate again. This decision is usually because of the complications they experienced after surgery.