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What Is Linaclotide Used For?

How Does It Work?

Linaclotide works by binding to an enzyme in the intestines known as guanylate cyclase-C (GC-C). When linaclotide binds to GC-C, it causes the enzyme to become active. Activated GC-C increases the amount of fluid in the intestines, and accelerates movement of content through the intestines. This helps relieve symptoms of constipation.
In animal studies, linaclotide decreased the activity of pain-sensing nerves in the intestines, which reduced pain. It is unknown whether the drug has the same effect on pain-sensing nerves in humans.
It is worthwhile to note that linaclotide works directly in the intestines. It is not absorbed into the bloodstream with normal use. 

Can Children Use It?

This drug is only approved for use in adults 18 years of age and older. Linaclotide may not be safe for use in children. It absolutely must not be given to children under the age of 6 years old, and should not be given to children under the age of 17 years old, as it may harm them.

Is It Safe for Older Adults to Use Linaclotide?

Older adults can use this medication. Very few people in linaclotide clinical studies were over the age of 65. Therefore, it is unknown whether those older than 65 will tolerate or respond to linaclotide any differently than younger age groups. Until more information is available, this medication should probably be used cautiously in older adults.

What About Off-Label Uses?

On occasion, your healthcare provider may recommend this medicine for something other than the uses described in this article. This is called an "off-label" use. At this time, there are no universally accepted off-label uses for linaclotide.

Linaclotide Drug Information

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