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Precautions and Warnings With Linaclotide

People who have an intestinal obstruction may not be able to safely take linaclotide. Warnings and precautions also apply to women who are pregnant or breastfeeding, as well as people who have certain allergies. Although linaclotide is unlikely to react with other drugs, talk to your healthcare provider about all products you are taking.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking linaclotide (Linzess™) if you have:
  • An intestinal obstruction (a blockage of your bowel)
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Linaclotide Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • The most common side effect of linaclotide is diarrhea. In most cases, diarrhea begins within two weeks of starting treatment. If you have severe diarrhea while taking linaclotide, stop the medication and contact your healthcare provider.
  • In animal studies, linaclotide caused death when given to young mice. Based on these studies, the medication may not be safe for use in children. Linaclotide must not be used in children younger than 6 years of age, and should not be used in children age 6 to 17 years old.
  • Linaclotide is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Linzess and Pregnancy).
  • It is unknown if linaclotide passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Linzess and Breastfeeding).

Linaclotide Drug Information

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