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Linaclotide Side Effects

Common Side Effects

Linaclotide has been studied extensively in clinical trials. In these studies, one group of people received the real medication, while another group was given a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common side effects of linaclotide included:
  • Diarrhea -- in up to 20 percent of people
  • Abdominal (stomach) pain -- up to 7 percent
  • Gas -- up to 6 percent
  • Upper respiratory tract infection, such as the common cold -- up to 5 percent
  • Headache -- up to 4 percent
  • Stomach flu -- up to 3 percent
  • Bloating or fullness in the stomach (distention) -- up to 3 percent
  • Sinus infection -- up to 3 percent.
Other common side effects, occurring in 1 percent to 2 percent of people, included:
  • Heartburn or indigestion
  • Vomiting
  • Fatigue
  • Stool incontinence.

Final Thoughts

You may experience some or none of the linaclotide side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking linaclotide or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.

Linaclotide Drug Information

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