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Linaclotide

Clinical Effects for Linaclotide

Linaclotide has been studied in people with irritable bowel syndrome with constipation (IBS-C) and people with chronic idiopathic (unknown cause) constipation. In these studies, linaclotide was shown to help relieve symptoms, including abdominal (stomach) pain and incomplete bowel movements.
 
Linaclotide for IBS-C
In IBS-C studies, 34.3 to 38.9 percent of people given linaclotide had at least a 30 percent reduction in abdominal (stomach) pain for at least 9 out of 12 weeks of treatment. In comparison, only 19.6 to 27.1 percent of those given a placebo (a "sugar pill" with no active ingredient) had the same reduction in abdominal pain.
 
Researchers also looked at how many people responded to treatment by having at least:
 
  • Three complete bowel movements without the use of laxatives
  • One more complete bowel movement (without needing laxatives) a week than they normally had before starting treatment.
 
Of those given linaclotide, 18 percent to 19.5 percent responded by meeting the above criteria for at least 9 out of 12 weeks of treatment. In comparison, only 5 percent to 6.3 percent of those given a placebo met the above criteria.
 
Linaclotide for Chronic Idiopathic Constipation
In studies of chronic idiopathic constipation, 15.5 percent to 20.3 percent of people given linaclotide had at least 3 complete bowel movements a week and at least 1 more bowel movement a week than they normally had for at least 9 out of 12 weeks. In comparison, 3.3 percent to 5.6 percent of people given a placebo had the same response.
 
In addition, those given linaclotide had a greater improvement, on average, in the number of bowel movements they had a week compared with those given a placebo. People taking linaclotide were also less likely to have lumpy or hard stools.
 

Linaclotide Drug Information

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