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Linaclotide

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
 
  • An intestinal obstruction (a blockage of your bowel)
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
   
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Linaclotide to learn more, including information on who should not take the drug.)
 

How Does It Work?

Linaclotide works by binding to an enzyme in the intestines known as guanylate cyclase-C (GC-C). When linaclotide binds to GC-C, it causes the enzyme to become active. Activated GC-C increases the amount of fluid in the intestines, and accelerates movement of content through the intestines. This helps relieve symptoms of constipation.
 
In animal studies, linaclotide decreased the activity of pain-sensing nerves in the intestines, which reduced pain. It is unknown whether the drug has the same effect on pain-sensing nerves in humans.
 
It is worthwhile to note that linaclotide works directly in the intestines. It is not absorbed into the bloodstream with normal use. 
 

Linaclotide Drug Information

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