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Linaclotide Dosage

With linaclotide, the dosage will be calculated based on a number of factors, such as whether you develop side effects and the reason you are taking it. This medication comes as capsules that are taken once a day on an empty stomach. Make sure to swallow the capsules whole; do not crush, chew, or open them.

An Introduction to Your Dosage of Linaclotide

The dose of linaclotide (Linzess™) your healthcare provider recommends may vary, depending on a couple of factors, including:
  • The reason you are taking it
  • Side effects you may have.
As is always the case, do not adjust your dosage of linaclotide unless your healthcare provider specifically tells you to do so.

What Is the Linaclotide Dose for Irritable Bowel Syndrome With Constipation?

The standard dosage of linaclotide for irritable bowel syndrome with constipation is 290 mcg once a day. Linaclotide is taken in the morning, at least 30 minutes before your first meal of the day. Talk to your healthcare provider if you have bothersome side effects on this amount. It is possible that your dosage could be reduced.

Linaclotide Dosing Guidelines for Chronic Idiopathic Constipation

The standard dose of linaclotide for chronic idiopathic constipation is 145 mcg once a day. In clinical studies, doses of 290 mcg a day did not work any better than the 145 mcg a day dose. You will usually take your dose in the morning, at least 30 minutes before your first meal of the day.

General Information on Taking Linaclotide

Some considerations to keep in mind during treatment with linaclotide include the following:
  • Linaclotide comes in the form of a capsule. It is usually taken by mouth once a day.
  • You should take linaclotide on an empty stomach, at least 30 minutes before your first meal of the day.
  • Do not crush, chew, or open the capsules; make sure to swallow them whole.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your linaclotide dosage, please talk with your healthcare provider, nurse, or pharmacist.

Linaclotide Drug Information

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