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Drug Interactions With Ethacrynic Acid

Drug interactions with ethacrynic acid may occur if the diuretic is taken with nonsteroidal anti-inflammatory drugs, blood pressure medications, or salicylates. These interactions can increase your risk of extremely low blood pressure, permanent hearing loss, and low potassium levels. If drug interactions with ethacrynic acid are a concern, your healthcare provider may adjust your dosages or monitor you more closely.

 

Drug Interactions With Ethacrynic Acid: An Introduction

Ethacrynic acid (Edecrin®) can potentially interact with a number of other medicines. Some of these drug interactions with ethacrynic acid can include:
 
  • Aminoglycoside antibiotics, such as:
 
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin
 
 
  • Corticosteroids, such as:
 
    • Prednisone
    • Hydrocortisone (Cortef®)
    • Dexamethasone (Decadron®, Dexone®, Hexadrol®)
 
  • Digoxin (Digitek®, Lanoxin®)
 
 
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
  • Salicylates, such as:
 
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Ethacrynic Acid Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;