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Drug Interactions With Ethacrynic Acid

Ethacrynic Acid Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when ethacrynic acid is combined with any of the drugs listed above.
 
Aminoglycoside Antibiotics
Ethacrynic acid should not be combined with aminoglycoside antibiotics unless absolutely necessary. Taking these two medications together can increase the risk of permanent hearing loss.
 
Blood Pressure Medicines
When taking ethacrynic acid with a high blood pressure medication, your blood pressure may decrease too much. In order to decrease the chances of developing this interaction, your healthcare provider may monitor you more closely and/or change the dose of either medicine.
 
Corticosteroids
Taking ethacrynic acid with corticosteroids may increase your risk of low potassium levels (hypokalemia). To prevent this interaction from occurring, your healthcare provider should check your potassium levels and may need to take steps to correct your potassium level.
 
Digoxin
Ethacrynic acid should be used with caution in people taking digoxin. It can cause low potassium levels (hypokalemia), which can be especially dangerous for people taking digoxin.
 
Lithium
Taking ethacrynic acid with lithium may increase the level of lithium in your blood, potentially increasing your chance of side effects. In general, people are not advised to take lithium at the same time as diuretics, including ethacrynic acid. Depending on your situation, your healthcare provider may need to monitor your lithium level more closely and/or change your lithium dose.
 
Nonsteroidal Anti-Inflammatory Drugs
If ethacrynic acid is taken with NSAIDs, it can make ethacrynic acid less effective and may increase your risk of side effects. Your healthcare provider may need to increase your dose of ethacrynic acid or suggest an alternative to NSAIDs.
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