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Dyrenium Warnings and Precautions

Before you start treatment with Dyrenium, warnings and precautions for the drug should be reviewed with your healthcare provider or pharmacist. It is important to know that the medication may cause kidney stones, high blood sugar, or high potassium levels in your blood. Dyrenium warnings and precautions also apply to those with diabetes, gout, or liver disease.

Dyrenium: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Dyrenium® (triamterene) if you have:
  • Liver disease, including cirrhosis
  • Kidney disease or kidney failure
  • A history of kidney stones
  • Diabetes
  • Systemic lupus erythematosus (lupus or SLE)
  • Gout
  • Fluid or electrolyte problems
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or trying to become pregnant
  • Breastfeeding.
Tell your healthcare provider about all medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Dyrenium Warnings and Precautions

Warnings and precautions to be aware of prior to taking Dyrenium include the following:
  • The medication can cause high potassium levels (hyperkalemia). If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. These symptoms may include:
    • Abnormal sensations, such as burning, tingling, or pricking
    • Muscle weakness
    • Low heart rate (bradycardia).
  • Do not use salt substitutes while taking Dyrenium. Salt substitutes usually contain potassium, and combining them with Dyrenium can increase the risk of high potassium levels in your blood (hyperkalemia). Herb-type salt substitutes that do not contain potassium are okay to use.
  • A number of medicines can interact with Dyrenium (see Dyrenium Drug Interactions).
  • Dyrenium has been reported to cause kidney stones. Talk to your healthcare provider before taking the medication if you have had kidney stones in the past.
  • Dyrenium is also known to worsen gout.
  • Dyrenium may cause high blood sugar (hyperglycemia) in people with diabetes. Your healthcare provider may need to adjust your dose of insulin or oral diabetes medication.
  • Dyrenium is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Talk to your healthcare provider about the risks and benefits of using the drug while pregnant (see Dyrenium and Pregnancy).
  • It is not known if Dyrenium passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Dyrenium and Breastfeeding).
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Dyrenium Drug Information

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