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Bumex Warnings and Precautions

An awareness of Bumex warnings and precautions can help ensure a safe treatment process. These include the risk of extremely low blood pressure, possible hearing loss, and the danger of taking the medication while pregnant. Bumex warnings and precautions also extend to those who have certain allergies, are producing very little urine, or who experience a worsening of kidney function while taking the drug.

Bumex: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Bumex® (bumetanide) if you have:
  • Liver disease, including cirrhosis
  • Kidney disease or kidney failure
  • Diabetes
  • Gout
  • Fluid or electrolyte problems
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Tell your healthcare provider about all of the medicines you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Bumex Warnings and Precautions

Warnings and precautions to be aware of prior to taking Bumex include the following:
  • If kidney problems seem to be getting worse (especially for those with severe kidney disease), Bumex should be stopped because the medicine can make kidney problems worse.
  • Bumex can cause hearing loss. Sometimes, this hearing loss is permanent. It is more common when high doses of the drug are given intravenously or when combined with other medications that can cause hearing loss. Let your healthcare provider know right away if you notice hearing loss or ringing in the ears (tinnitus).
  • People who are allergic to sulfonamides ("sulfa" drugs) may also be allergic to Bumex.
  • There are a number of medicines that Bumex can interact with (see Bumex Drug Interactions).
  • The medication may cause extremely low blood pressure in some people. This is more likely to happen when the medicine is first started or the dosage is changed. It is also more likely to happen in people who are on dialysis, who have congestive heart failure, who have diarrhea or vomiting, or who have excessive sweating. This is why it is important to drink fluids regularly while taking the drug. If you have any possible symptoms of low blood pressure, such as dizziness, lightheadedness, or fainting, contact your healthcare provider. If you have fainted, stop taking Bumex until you have talked to your healthcare provider.
Also, make sure not to drive, operate any heavy machinery, or perform any other tasks that require alertness until you know how the medication affects you.
  • Bumex may affect electrolytes in the blood (including sodium, calcium, potassium, magnesium, and chloride). Therefore, your healthcare provider will regularly check these levels. If you notice any symptoms of a possible electrolyte imbalance, contact your healthcare provider. Symptoms may include:
o Dry mouth
o Thirst
o Weakness
o Lethargy
o Drowsiness
o Restlessness
o Muscle pain or muscle cramps
o Low blood pressure (hypotension)
o Decreased urination
o A rapid heart rate (tachycardia) or irregular heart rhythms (arrhythmia)
o Nausea or vomiting. 
  • Bumex is also known to make gout worse.
  • The medication may cause high blood sugar (hyperglycemia) in diabetics or, in some cases, even cause diabetes in people without a history of the condition.
  • Bumex is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using the drug during pregnancy (see Bumex and Pregnancy).
  • It is not known if Bumex passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider (see Bumex and Breastfeeding).
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