Drug Interactions With Budesonide ER
The following sections explain in detail the potentially negative reactions that can occur when budesonide ER is combined with any of the drugs listed above.
CYP 3A4 Inhibitors
Budesonide ER is broken down (metabolized) in the liver by CYP 3A4 enzymes. Many other drugs known as CYP 3A4 inhibitors slow down the activity of these enzymes and can lead to increased levels of budesonide ER in the blood, potentially increasing the risk of steroid side effects. Talk with your healthcare provider before combining such medications. It may be recommended to avoid combining strong CYP 3A4 inhibitors with budesonide ER.
Grapefruit and Grapefruit Juice
Eating grapefruit or drinking grapefruit juice can increase the level of budesonide ER in your blood. It is recommended that you do not eat grapefruit or drink grapefruit juice the entire time you are taking budesonide ER.
Medications That Reduce Stomach Acid
Budesonide ER tablets have a special coating that will not dissolve in an acidic environment, such as the stomach, but will dissolve in a nonacidic environment like the intestines. Medications that lower stomach acid may cause the coating to dissolve too soon, perhaps making budesonide ER less effective. Check with your healthcare provider before combining such medications.
It is possible that not all budesonide ER drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.