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Precautions and Warnings With Alosetron

Prior to prescribing alosetron, your healthcare provider will ask about your medical history and all other drugs you are taking. Reviewing safety precautions such as these can help prevent dangerous drug interactions with alosetron. Other warnings apply to people who have a blood-clotting disorder, intestinal problems, or certain other medical conditions.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking alosetron hydrochloride (Lotronex®) if you have:
 
  • Constipation, or have had severe constipation or constipation that keeps coming back
  • Had intestinal problems due to constipation, including:
    • An obstruction (a blockage of your bowel)
    • Narrowing (stricture)
    • Tear (perforation)
    • Widening (toxic megacolon)
 
  • Had problems with blood flow to your intestines, such as ischemic colitis
  • Had a blood clot or blood-clotting problems
  • Had ulcerative colitis
  • Had Crohn's disease
  • Had diverticulitis
  • Liver disease, such as hepatitis or liver failure
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you:
 
  • Do not understand the Alosetron Medication Guide or Patient Acknowledgement Form, or if you are not willing to follow them
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Alosetron Drug Information

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