Digestive System Channel
Topics
Medications
Quicklinks
Related Channels

Drug Interactions With Alosetron

More Detail on Drug Interactions With Alosetron

The following sections explain in detail the potentially negative reactions that can occur when alosetron is combined with any of the drugs listed above.
 
Apomorphine
The manufacturer of apomorphine recommends it not be used with medications like alosetron (known as 5-HT3 antagonists), as the combination may cause a dangerously low drop in blood pressure.
 
CYP 1A2 Inhibitor Medications
The body breaks down alosetron using enzymes in the liver known as CYP 1A2 enzymes. Some other medications (known as CYP 1A2 inhibitors) can decrease the activity of these enzymes. Combining alosetron with one of these CYP 1A2 inhibitors may increase the amount of alosetron in the body, potentially increasing your risk for side effects.
 
Alosetron should not be taken in combination with fluvoxamine. Taking it with other CYP 1A2 inhibitors should also be avoided if possible.
 
CYP 2C9 Inhibitor Medications
The liver breaks down alosetron using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Thus, combining alosetron with one of these drugs may increase the amount of alosetron in the body, potentially increasing your risk for side effects. While these medicines can be taken together without problems, you may need to watch closely for any possible alosetron side effects if you take it in combination with a CYP 2C9 inhibitor.
 
CYP 3A4 Inducer Medications
The liver breaks down alosetron using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining alosetron with one of these drugs may decrease the level of alosetron in your body, potentially making it less effective. Talk to your healthcare provider if you take alosetron with a CYP 3A4 inducer, especially if alosetron is not adequately controlling your symptoms. 
 
CYP 3A4 Inhibitor Medications
The liver breaks down alosetron using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining alosetron with one of these drugs may increase the level of alosetron in your body, potentially increasing your risk for alosetron side effects. Talk to your healthcare provider about this possible interaction if you take these medicines together. Also, let your healthcare provider know if you develop any potential alosetron side effects.
 
Fluvoxamine
Fluvoxamine can increase blood levels of alosetron, increasing the risk for potentially serious alosetron side effects. You should not take alosetron if you take fluvoxamine.
 

Alosetron Drug Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.