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Alosetron is prescribed to help in the treatment of severe diarrhea-predominant irritable bowel syndrome (IBS) in women. This drug is only used after other treatments have been tried but have not adequately controlled IBS symptoms. Although most women tolerate this drug well, side effects can occur and may include constipation, abdominal (stomach) pain, and nausea.

What Is Alosetron?

Alosetron hydrochloride (Lotronex®) is a prescription medication approved to treat women with severe diarrhea-predominant irritable bowel syndrome (IBS) who have had symptoms for at least six months, and who have not been adequately helped by other treatments. IBS with diarrhea is considered severe if it is associated with at least one of the following:
  • Frequent and severe abdominal (stomach) pain and discomfort
  • Frequent urgency to have a bowel movement or "accidents" involving loose stools or diarrhea (fecal incontinence)
  • The condition causes disability, or disrupts daily activities at work or home.
Alosetron is not safe for everyone. Because of potentially serious bowel side effects that can occur with alosetron use, this drug is restricted to people who have severe IBS that has not responded to safer treatments. The medication can only be prescribed by healthcare providers who enroll in a special program and understand the unique benefits and risks of alosetron treatment. 
(Click What Is Alosetron Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, alosetron can cause side effects. However, not everyone who takes the drug will experience problems. Most people tolerate it quite well.
If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Some of the most common alosetron side effects include but are not limited to:
  • Constipation
  • Abdominal (stomach) pain and discomfort
  • Nausea.
(Click Alosetron Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)

Alosetron Drug Information

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