Your recommended dose of alosetron will depend on how you respond to it, whether you develop side effects, and other factors. If you develop side effects, your healthcare provider may lower your amount. Alosetron comes as a tablet that is taken once or twice daily. If you become constipated while taking this drug, you should stop taking it and contact your healthcare provider.
An Introduction to Your Dosage of Alosetron
The dose of alosetron hydrochloride (Lotronex®) your healthcare provider recommends may vary, depending on a few factors, including:
- How you respond to it
- Side effects you develop
- Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Recommended Alosetron Dosing Guidelines
The standard initial alosetron dosage for treating diarrhea-predominant irritable bowel syndrome (IBS) is 0.5 mg twice a day. You will continue to take this dosage for at least four weeks to see how you respond to the medicine, and make sure you tolerate it well. If you become constipated, your dosage will need to be reduced to 0.5 mg once a day.
If your symptoms are well controlled after four weeks, and you did not develop constipation or other side effects, you will be maintained on your current dose. If, however, your symptoms are not adequately controlled, and you tolerated the medication, your healthcare provider may choose to increase your dose to a maximum of 1 mg twice a day.
If you become constipated anytime during treatment, you should stop taking alosetron and contact your healthcare provider. Alosetron has been reported to cause serious, potentially life-threatening constipation-related problems.
People who have taken alosetron 1 mg twice daily for 4 weeks, and whose symptoms are still not adequately controlled, should stop taking the medicine and contact their healthcare provider. Alosetron might not be the best medication for them.